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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of research design, like recruitment and consent in adherence, as well as the use of commonly available equipment.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity, can cause problems with the design of the trial.
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The aim of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. They are usually commissioned by practitioners and policy makers to guide their decision-making. They can be used to determine the causal relationship between an intervention and its results. However, they shouldn't be used as a substitute for explanation trials.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should be an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatic thinking. However, 프라그마틱 무료슬롯 it is important to note that the majority of these studies were conducted in primary care settings.