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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of routinely available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and included participants from various geographical areas. This kind of heterogeneity, which is essential for pragmatic trials to be valid and reduce bias in results is also essential. However, too much heterogeneity can result in problems with the trial design.
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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by policymakers and practitioners to inform their decisions. They can also be used to assess the causality of an intervention and its effects. However, they should not be used as a substitute for explanatory studies.
The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, 프라그마틱 슬롯 추천 which prove a physiological or clinical hypothesis and pragmatic trials that inform the policy and practice of. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and implementation of the intervention, 무료 프라그마틱 순위 (Click On this website) as well as follow-up.
There is a positive increase in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.