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It has established itself as one of the leading casino gaming platforms despite its relative infancy. The most recent releases include Wolves, a 5-reel video slot with a healthful RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.<br><br>Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually ordered by policymakers and practitioners to guide their decisions. They also provide a useful way to identify the causality between an intervention and its outcomes. They should not, however, be used to replace the need for explanation studies.<br><br>The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and follow-up.<br><br>There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.
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