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The most recent releases include Wolves, a 5-reel video slot with a healthful RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.<br><br>Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are typically commissioned by policymakers and practitioners to inform their decisions. They can also be used to assess the causality of an intervention and its effects. However, they should not be used as a substitute for explanatory studies.<br><br>The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials,  [https://www.hulkshare.com/rotateface1/ 프라그마틱 슬롯 추천] which prove a physiological or clinical hypothesis and pragmatic trials that inform the policy and practice of. 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